MET and Non-Small Cell Lung Cancer  (NSCLC) sign MET and Non-Small Cell Lung Cancer  (NSCLC) sign

In NSCLC,

Understand MET

MET alterations including

MET exon 14 skipping (METex14) are oncogenic alterations in NSCLC, and it’s important to know every patient's status.

Many different oncogenic alterations can contribute to the development of NSCLC.1
MET dysregulation drives oncogenic signaling in NSCLC.2
METex14 is an oncogenic alteration in NSCLC that is associated with poor prognosis.3-5

NSCLC, non-small cell lung cancer.

References

1. Yoda S, Dagogo-Jack I, Hata AN. Pharmacol Ther. 2019;193:20-30.
2. Kim JH, Kim HS, Kim BJ. J Cancer. 2018;9(10):1836-1845.
3. Drilon AD, Cappuzzo F, Ou SI, Camidge DR. J Thorac Oncol. 2017;12(1):15-26.
4. Awad MM, Leonardi GC, Kravets S, et al. Lung Cancer. 2019;133:96-102.
5. Tong JH, Yeung SF, Chan AWH, et al. Clin Cancer Res. 2016;22(12):3048-3056.

 


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